PMZ-2010 (Centhaquine), produced a dose-dependent reduction in post operative pain.
It may be a novel alternative to morphine treatment in post operative surgical pain.
It does not have sedative effect, no action on opiate receptors. Risk of respiratory depression is minimal.
PMZ-2010 (Centhaquine) has mild and short lived hypotensive and bradycardia action therefore less risk of severe fall in blood pressure as compared to clonidine or dexmedetomidine. It does not produce hypothermia as observed with clonidine.
PMZ-2010 (Centhaquine) has successfully completed human Phase I study (NCT02408731).
Post Operative Pain (PMZ-2010 (Centhaquine)