Endothelin-A receptor antagonists such as PMZ-2123 potentiate analgesic effects of morphine and oxycodone. Reduces the use of opioids and maintains adequate pain relief.
PMZ-2123 has the ability to eliminate and reverse opioid tolerance, patients who have already developed tolerance to opioids can be treated with PMZ-2123 and achieve adequate pain relief with lower doses of opioids.
The development of PMZ-2123 to potentiate analgesic effects of morphine and oxycodone and eliminate tolerance will have major clinical impact in reducing the use of opioids and maintain adequate pain relief. It will reduce the risk of abuse, misuse, addiction, overdose, and deaths due to prescription opioid analgesics.
Patents issued in United States.
Opioid Tolerance & Pain Management